Levels of vitamin D precursor in body could be better indicator of present health, future risks, claims study
Though the study showed that low levels of both free and bound vitamin D metabolites were associated with a higher risk of death, only the free precursor of vitamin D, 25-hydroxyvitamin D, was efficient in predicting future health problems
According to a study published in the journal Nature earlier this year, about 490 million people in India have a vitamin D deficiency. Vitamin D, also known as the sunshine vitamin, is one of the vitamins which are formed in the body itself. Vitamin D is present in the skin in the form of a precursor, 25-dihydroxyvitamin D, which gets activated to become 1,25-dihydroxyvitamin D after exposure to the sun. The active form of vitamin D, 1,25-dihydroxyvitamin D, helps in strengthening the bones and teeth, improving muscle strength and preventing fractures and is extremely necessary for the growth of bones in children.
However, in a recent study, presented at the online meeting of the European Society of Endocrinology 2020, scientists found that the free, precursor form of vitamin D found circulating in the bloodstream is a more accurate predictor of future health and disease risk, than the often-measured total vitamin D.
Predicting health risks with the help of vitamin D levels
Since 99 percent of the active form of vitamin D is bound to the proteins present in the blood, only 0.4 percent of 1,25-dihydroxyvitamin D and 0.03 percent of 25-dihydroxyvitamin D roam freely in the body and act as a better indicator of current health status and predictor of future risks.
To examine this, Dr Leen Antonio, along with his team from the University Hospitals Leuven, Belgium, examined the levels of free vitamin D metabolites in the bodies of 1,970 men from the 40-79 age group between the years 2003 and 2005. The data of these men were taken from the European Male Ageing Study. The scientists also took age, body mass index, the habit of smoking and other self-reported health issues into account.
The results of the study
While examining the results it was found that 524 men died during the follow-up and these men had a higher body mass index and lower physical activity levels.
The rest of the results showed that men who had the lowest levels of 1,25-dihydroxyvitamin D and 25-dihydroxyvitamin D were at increased risk of dying. The scientists further stated that the men who showed low levels of 25-dihydroxyvitamin D were more likely to die than those who had low levels of 1, 25-dihydroxyvitamin D.
It was concluded that though low levels of both free and bound vitamin D metabolites were associated with a higher risk of death, only the free precursor of vitamin D, that is 25-hydroxyvitamin D, was efficient in predicting the future health problems. So rather than examining the total vitamin D levels, the free vitamin D metabolites should be tested to determine any disease.
For more information, read our article on Vitamin D.
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