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Coronavirus News Updates: Covaxin displaying encouraging results in clinical trial, claims Bharat Biotech

Coronavirus News Updates: Covaxin, being developed in collaboration with the Indian Council of Medical Research and the National Institute of Virology, is now undergoing Phase 3 trials

FP Staff December 23, 2020 23:40:28 IST
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Coronavirus News Updates: Covaxin displaying encouraging results in clinical trial, claims Bharat Biotech

COVAXIN vaccine by Bharath Biotech.

Highlights

13:01 (ist)

Eminent Malayalam poet-activist Sugathakumari dies of COVID-19 complications

Acclaimed Malayalam poet and environmental activist Sugathakumari passed away Wednesday following COVID-19 complications at the Medical College Hospital in Thiruvananthapuram. She was 86.

For the past one week, the Padma Shri awardee had been hospitalised with severe pneumonia after testing positive for the novel coronavirus.

11:32 (ist)

Karnataka unlikely to postpone plan to reopen schools from 1 Jan 

The Karnataka government is unlikely to immediately change the plan to reopen schools from 1 January for some classes, The Hindu reported.

The state’s COVID-19 Technical Advisory Committee (TAC) that met on Tuesday in the light of the new strain of SARS-CoV-2 emerging, has recommended that the government should wait and watch the situation for the next four weeks and then take a call.

LIVE NEWS and UPDATES

Dec 23, 2020 - 23:29 (IST)

One more dies of COVID-19 in Noida, toll at 89

 

Uttar Pradesh's Gautam Buddh Nagar recorded one more fatality linked to COVID-19 that pushed the district's death toll to 89, while the infection tally surged to 24,673 with 67 new cases on Wednesday, official data showed. Active cases in the district rose to 579 from 572 the previous day, as the total recoveries crossed past 24,000, according to the data released by the UP health department for a 24-hour period.

The number of active cases in Gautam Buddh Nagar is the seventh highest in the state. On the brighter side, 59 more patients got discharged during the period with the overall recoveries reaching 24,005, the fifth highest in the state.

Gautam Buddh Nagar now has a death toll of 89 and a mortality rate of 0.36 percent. The recovery rate of patients reached 97.29 percent, the statistics showed. Meanwhile, the number of active COVID-19 cases in Uttar Pradesh came down to 16,378 from 16,691 on Tuesday while the overall recoveries reached 5,53,019 and the death toll climbed to 8,245 on Wednesday, the data showed. 

Dec 23, 2020 - 23:27 (IST)

41 fresh COVID-19 cases in UP's Muzaffarnagar

 

Forty-one fresh COVID-19 cases were reported in Muzaffarnagar, taking the number of active patients to 383 in the district on Wednesday, officials said.

According to DM Selvakumari J, 1,154 samples were received of which 41 tested positive while 77 recovered from the infection.

The total recoveries have gone up to 7,330 in the district with the latest discharges while the total cases now stands at 7,812. 

 

Dec 23, 2020 - 23:21 (IST)

Night curfew on 31 Dec in Rajasthan's cities

 
The Rajasthan government has imposed a night curfew on 31 December in all cities having a population of over one lakh. The restrictions will remain in place from 8 pm on 31 December to 6 am on 1 January, according to an order issued by the home department. No New Year party will be organised on the occasion while bursting of firecrackers will be banned. According to the order, markets will be closed at 7 pm. 

Dec 23, 2020 - 22:38 (IST)

Health secretary reviews status of passengers from UK

Union health secretary Rajesh Bhushan reviewed the status of passengers coming from the UK to India and found positive in Maharashtra, Karnataka, Telangana, Tamil Nadu, West Bengal, Goa, Punjab, Gujarat and Kerala and their response measures in a meeting held through video-conferencing.

ICMR DG; health secretaries of states and union territories; NHM MD; Arti Ahuja, Additional Secretary, Ministry of Health; Dr Sujeet Singh, Director, NCDC, and other senior health officials were also present in the meeting, a health ministry statement said.

The Standard Operating Procedure issued by the ministry on 22 December for Epidemiological Surveillance and Response in the context of new variant of SARS-CoV-2 virus detected in the UK was discussed in detail in the meeting.

Dec 23, 2020 - 22:26 (IST)

Covaxin shows encouraging results in clinical trials: Research paper

Covaxin, a COVID-19 vaccine being developed by Bharat Biotech, showed long-term antibody and T- cell (immune) memory responses three months after the shot in Phase 1 volunteers and tolerable safety outcomes in Phase 2 study, the city-based company has said, suggesting the antibodies may persist for six to 12 months.

In Phase 2, it also showed enhanced humoral and cell- mediated immune responses and the results were found in the safety and immunogenicity clinical trial of the vaccine candidate. Memory T cells are antigen-specific T cells that remain over a long term after an infection has been eliminated.

Covaxin, being developed in collaboration with the Indian Council of Medical Research and the National Institute of Virology, is now undergoing Phase 3 trials.

Dec 23, 2020 - 21:57 (IST)

Canada approves second COVID vaccine

Canada has approved the COVID-19 vaccine developed by American biotech firm Moderna, the health department announced Wednesday, two weeks after authorising immunisations with the Pfizer/BioNTech shot.


The decision makes Canada the second country to greenlight the Moderna vaccine, after the US.


"Health Canada... has determined that the Moderna vaccine meets the department's stringent safety, efficacy and quality requirements," it said in a statement.


The authorisation is a "critical step," the statement continued.

Dec 23, 2020 - 21:14 (IST)

Britain announces travel curbs on South Africa

Britain on Wednesday introduced restrictions on travel from South Africa over the spread of another new variant of coronavirus, reported news agency AFP. UK Health Minister Matt Hancock said. "We're placing immediate restrictions on travel from South Africa," Hancock said, adding that two cases of the "highly concerning" new virus strain had been discovered in Britain.  According to the BBC, both people had travelled to South Africa, where the variant has been linked to a surge in cases. Persons with recent travel history to South Africa or those who came in contact with them have been asked to quarantine immediately, said the report.

Dec 23, 2020 - 21:02 (IST)

No public gathering during Christmas and New Year in Gujarat

In view of COVID-19 pandemic,  public prayers or gatherings will not be allowed in Gujarat during Christmas and New Year, the state government said on Wednesday. At the same time, the government allowed local authorities to take a call on allowing celebrations at public places "in special cases".
 
"In view of the coronavirus situation in the state, no religious public gatherings, rallies, prayers in public places or public procession will be allowed during Christmas and New Year," a release quoted Minister of State for Home Pradeepsinh Jadeja as saying. If permission is granted in special cases, the
administration must ensure full compliance with COVID-19 related guidelines at such places and ensure that only a limited number of people attend such events," the release said.
 
PTI

Dec 23, 2020 - 20:45 (IST)

Qatar starts vaccinating priority groups

Qatar began inoculating a prioritised group of citizens and residents against the coronavirus with the vaccine created by Pfizer and its German partner BioNTech. Qatar state-run media reported that several health centres across the tiny energy-rich country started providing the Pfizer vaccine free of charge on Wednesday to older adults, healthcare workers, people in nursing homes and those with underlying health conditions.  Authorities approved the Pfizer vaccine for emergency use earlier this week. The government has also signed a supply agreement with American drugmaker Moderna.
 
AP

Dec 23, 2020 - 20:40 (IST)

Delhi HC directs AAP govt to frame SOPs for post-COVID complications

The Delhi High Court directed the AAP government to frame standard operating procedures (SOPs) to deal with post COVID-19 complications relating to the lungs and other vital organs in those who have recovered from the coronavirus infection. The high court further said that in view of the new coronavirus strain in the UK, from where a large number of people arrived before the Centre suspended the flights between the two countries, the Delhi government should "ensure prompt and adequate testing and follow up in respect of those found positive with all seriousness to avoid another spate of infection in the city". The new strain can spread faster. The directions were issued by a bench of Justices Hima Kohli and Subramonium Prasad while hearing a PIL by advocate Rakesh Malhotra seeking increase in the COVID-19 testing numbers in the national capital and getting speedy results.
 
PTI

Coronavirus News LATEST Updates: Covaxin, being developed in collaboration with the Indian Council of Medical Research and the National Institute of Virology, is now undergoing Phase 3 trials.

Health Canada approved the COVID-19 vaccine developed by American biotech firm Moderna two weeks after authorising immunisations with the Pfizer/BioNTech shot.

The UK has announced immediate quarantine for anyone who has travelled to South Africa, with reports quoting UK health secretary Matt Hancock as saying that the South Africa variant is more infectious than the UK variant.

In view of COVID-19 pandemic, public prayers or gatherings will not be allowed in Gujarat during Christmas and New Year, the state government said on Wednesday. At the same time, the government allowed local authorities to take a call on allowing celebrations at public places "in special cases".

A total of 11 people, who travelled from the UK to Delhi in four flights, have tested positive for coronavirus , said reports. As per India Today, over 950 persons have been tested so far and the samples which tested positive have been sent to the NCDC for genome sequencing.

As many as 1,688 passengers arrived at the Mumbai international airport from the UK and other countries since Monday midnight and 745 of them were quarantined in the city, a civic official said on Wednesday. Mumbai municipal commissioner on Monday had announced that all passengers arriving from the UK, other European countries and from West Asia will have to be under institutional quarantine for seven days.

It could not be ascertained if any of these 745 passengers were found to have COVID-19 symptoms.

Amid concerns over a new variant of the coronavirus detected in the United Kingdom, Uttar Pradesh Chief Minister Yogi Adityanath said that those who came to the state from abroad between 25 November and 8 December should undergo tests for detection of COVID-19 . Those who arrive in UP from abroad after 9 December must undergo RT-PCR test, he told officials at a review meeting.

Board examinations for Classes 10 and 12 will be held in June one after another, said West Bengal Education Minister Partha Chatterjee. The class 10 (Madhyamik) exams will be held first and the class 12 (Ucchya Madhyamik) examinations after that, he said.

Union Education Minister Ramesh Pokhriyal 'Nishank' had earlier ruled out conducting board examinations till February next year in view of the COVID-19 situation.

Delhi health minister Satyendar Jain on Wednesday said people who have arrived in Delhi from the UK are being rigorously traced and tested for any COVID-19 -like symptoms. He asserted that the coronavirus situation in the city is under control with the positivity rate plummeting to below one percent.

The Maharashtra government on Wednesday widened the scope of the night curfew, which was imposed in municipal limits on Tuesday amid growing concerns over the emergence of a new coronavirus strain in UK.

As a precautionary step amid growing concerns over the mutated COVID-19 variant, the state government clamped a curfew from 11 pm to 6 am in the limits of 27 municipal corporations, including Mumbai, from 22 December to 5 January.

Taking to Twitter, the former Congress president also shared a ' COVID-19 vaccinations' chart showing China ahead followed by the United States, United Kingdom and Russia.

Chilean authorities announced that at least 58 people that were at two military bases in Antarctica or on a navy ship that went to the continent tested positive for the new coronavirus .

The night curfew has been imposed to contain the coronavirus strain found in the UK. We are also monitoring international passengers arriving in Karnataka, said health minister Dr K Sudhakar on Wednesday.

The number of people who have recuperated from the disease surged to 96,63,382 pushing the national recovery rate to 95.69 percent, while the COVID-19 case fatality rate stands at 1.45 percent.

According to BBMP officials, Prasad had slight fever and related symptoms and has been admitted to Mallige Hospital in Bengaluru.

India reported 23,950 fresh cases of the novel coronavirus and 333 deaths in the past 24 hours, said the Union health ministry on Wednesday, as the country continued to witness a declining trend in average daily infections.

A total of 16,42,68,721 COVID-19 samples have been tested up to 22 December. Of these, 10,98,164 samples were tested on Tuesday alone, said ICMR.

There is no need to panic over the mutated variant of SARS-CoV-2 detected in the UK, the government said on Tuesday, asserting that no such variant or any significant mutation in the coronavirus strain has been seen in India yet.

NITI Aayog member (health) Dr VK Paul, during a press briefing, also said the mutated SARS-CoV-2 strain detected in the UK will have no impact on the potential of emerging vaccines which are being developed in India and other countries.

"As of now, based on our discussions, deep understanding of data available and our deep assessment, there is no need to panic but it is a cause to be more vigilant," he said.

Paul said that "this new challenge, we have to counter with our comprehensive efforts". "We will be safe if we suppress the genomic sequence," he said.

There is no change in the treatment guidelines so far due to this mutation and the vaccines that are being developed, particularly those in the country, will not be impacted, Paul said.

This variant of the virus in the UK is defined by a set of 17 changes or mutations, he said and added that its tendency to enter the body's cells has become higher and transmissibility has also increased with mutation.

"It is also being said that in these viruses, the transmissibility has increased by 70 percent, you can also call them super spreader in a way. This virus increases infectiousness but does not increase propensity for death or hospitalisation or severity of the disease. What is affected is the tendency to affect more people that by itself is a cause of concern. It is an adverse development," he said.

Paul said that there is no need to "panic" and added that "we are yet to spot such a virus in our country and for which there are intensive efforts in the offing."

BioNTech CEO confident vaccine will work on UK variant

German pharmaceutical company BioNTech is confident that its coronavirus vaccine works against the new UK variant, but further studies are needed to be completely sure, its chief executive said Tuesday.

The variant, detected mainly in London and the southeast of England in recent weeks, has sparked concern worldwide because of signs that it may spread more easily. While there is no indication it causes more serious illness, numerous countries in Europe and beyond have restricted travel from the UK as a result.

"We don’t know at the moment if our vaccine is also able to provide protection against this new variant," CEO Ugur Sahin told a news conference the day after the vaccine was approved for use in the European Union. "But scientifically, it is highly likely that the immune response by this vaccine also can deal with the new virus variants."

Sahin said that the proteins on the UK variant are 99 percent the same as on the prevailing strains, and therefore BioNTech has "scientific confidence" that its vaccine will be effective.

"But we will know it only if the experiment is done and we will need about two weeks from now to get the data," he said. "The likelihood that our vaccine works is relatively high."

Should the vaccine need to be adjusted for the new variant the company could do so in about six weeks, Sahin said, though regulators might have to approve the changes before the shots can be used.

Having to adjust the vaccine would be a blow for the rollout of immunization campaigns and the effort to rein in the pandemic that has so far killed more than 1.7 million people worldwide.

BioNTech's vaccine, which was developed together with US pharmaceutical company Pfizer, has been authorized for use in more than 45 countries including Britain, the United States and the EU. Hundreds of thousands of people have already received the shots.

The companies submitted data to regulators showing the vaccine, which goes by the brand name COMIRNATY in Europe, is 95 percent effective in preventing infection with COVID-19 .

"All countries across the EU that have requested doses will receive them in the next five days, the very initial supply, and that will be followed up next week with further supplies," said Sean Marett, BioNTech's chief commercial officer.

The company is distributing super-cooled batches of vaccine across the 27-nation bloc by truck and plane from a Pfizer plant in Belgium. The EU has ordered 200 million doses of the vaccine, with an option of 100 million more.

Marett said BioNTech is examining ways to deliver more than the 1.3 billion doses currently planned worldwide for 2021.

"As BioNTech we’re always interested in looking at facilities that could help boost up production next year," he told The Associated Press, citing the recent acquisition of a plant in Germany from Novartis. "We would be looking to do very quick transactions if we can."

BioNTech expects demand for COVID vaccines to continue in the future.

"This virus is not going to go away," Marett told The AP. "It'll be there at least for the next decade, and therefore it’s important that if people so choose, they should get vaccinated."

It's also still unclear how long the immunity conferred by a vaccine lasts.

"It’s quite possible that we will need to give a booster injection," Marett said. "So a repeat injection, maybe as frequently as one year, maybe every two years. We don’t know yet."

Several EU countries have said they plan to start vaccinating on Sunday. Germany's health minister, Jens Spahn, said he expects the country to receive more than 1.3 million doses by the end of this year.

Germany is among the European countries that have banned flights from the UK because of the new variant there.

"We want to avoid for as long as we can that a possibly dangerous virus variant spreads to continental Europe," said Spahn.

But Lothar Wieler, the head of Germany’s national disease control center, said it was very likely the UK variant is already circulating in Germany.

Wieler, who heads the Robert Koch Institute, said it was common for viruses' genetic material to change, and that can affect how transmissible they are.

"Whether that is really the case with the variant in England is not yet entirely clear," Wieler said. "What is clear is that the more widely viruses spread, the more opportunity they have to change."

A leading German virologist who was initially skeptical about reports that the strain was much more contagious voiced concern after seeing further data. Christian Drosten, a professor of virology at Berlin's Charite hospital, tweeted that "unfortunately it doesn’t look good".

But Drosten added: "What is positive is that cases with the mutation so far only increased in areas where the overall incidence was high or rising. So contact reduction also works against the spread of the mutation."

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