India have unearthed new talent in the series against England, which has been sealed at 3-1, such as Dhruv Jurel and Sarfaraz Khan, in the absence of Virat Kohli and the injured KL Rahul.
Devdutt Padikkal is in line for his debut in place of Rajat Patidar, who has managed just 63 runs in six innings in his maiden series.
Left-handed opener Yashasvi Jaiswal leads the series batting with 655 runs, including two double centuries.
India pace spearhead Jasprit Bumrah will return after being rested but the focus will be on R Ashwin, 37, who made his debut in 2011 and will be playing his 100th Test.
Ashwin has 507 Test victims, second only to Anil Kumble’s 619 wickets on India’s all-time list.
“It’s a pretty big occasion – more than the destination, the journey has been very special,” Ashwin told reporters.
“But it doesn’t change anything… 3-1 scoreline is on the board, and despite the scoreline, you want to win every Test match that you play.”
In the other camp, Struggling Jonny Bairstow looks to be fighting to save his Test career when the fifth and final match against India begins in Dharamsala on Thursday.
Bairstow will win his 100th cap as an England player, who have already lost the series 3-1, try to salvage some pride in the high-altitude and chilly Himalayan hill town.
Bairstow said Tuesday that his 100th Test would mean “a hell of a lot”, he told reporters.
Bairstow, the former wicketkeeper, is in the side as a specialist batter, after Ben Foakes took over behind the stumps, but has scored just 170 runs at an average of 21.25 during the series.
The 34-year-old has struggled since returning to the side last year, after breaking his leg in a freak golfing accident.
He has played 10 Tests since recovering, but has not scored a century and has a highest of only 38 in eight innings in India.
Bairstow is renowned as an attacking batsman and at number five in the order is crucial to England’s aggressive “Bazball” style of cricket.
Bairstow showed glimpses of a return to form in the fourth Test but could not convert good starts, where he reached 38 and 30 in each innings respectively, into substantial scores.
The weather in Dharamsala could play a huge part in the match. The picturesque ground is surrounded by snow-capped peaks at an altitude of 1,317 metres (4,320 feet).
There is a risk of sleet and forecasts say temperatures could plunge as low as 1C on Thursday.