Manchester City's Premier League title defence fell apart at the seams in a 3-1 defeat to Southampton on Saturday when goalkeeper Joe Hart committed a howler and Gareth Barry scored a bizarre own goal.
Manchester United can increase their lead over City at the top to 12 points with 12 games left if they win at home to Everton on Sunday (1600 GMT) after coach Mauricio Pochettino sealed his first win for 15th-placed Southampton.
The unstoppable Gareth Bale earlier scored twice in Tottenham Hotspur's 2-1 home victory over Newcastle United while rivals Chelsea and Arsenal also won to add spice to the race for the Champions League spots.
Chelsea stayed third, a point ahead of Spurs and four behind City, after a 4-1 home success over third-bottom Wigan Athletic while 10-man Arsenal beat Sunderland 1-0 away thanks to Santi Cazorla's strike to leapfrog Everton into fifth.
Basement side Queens Park Rangers suffered a big blow in a 4-1 defeat at Swansea City but fourth-bottom Reading failed to increase the six-point gap with a 2-1 loss at Stoke City. Mid-table Norwich City and Fulham managed a goalless stalemate.
Southampton had previously managed two draws and a defeat since Argentine Pochettino replaced the sacked Nigel Adkins in an unpopular move, but their home victory over City was fully deserved even if the visitors gave them a big helping hand.
First Barry lost the ball in midfield after seven minutes and Jason Puncheon stormed forward before coolly finishing off a rebound after Hart's sprawling stop.
Hart, who saved a Ronaldinho penalty during an excellent display for England in a friendly against Brazil on Wednesday, then let a Rickie Lambert shot go through his legs and Steven Davis slid the ball in midway through the first period.
Roberto Mancini had been confidently predicting his side would make up the gap to United, like last season, but he looked stunned in the dugout as City struggled with midfielder Javi Garcia at centre back after Vincent Kompany was again ruled out.
A rampant break from the edge of their own area gave City hope in the 39th minute, with Edin Dzeko flicking the ball home while falling over after tremendous work by the Bosnian, David Silva and Pablo Zabaleta.
City fans have been used to great comebacks in recent times, not least when they beat QPR 3-2 in stoppage time on the final day last season to clinch the title, but this time there was to be incompetence rather than heroics.
A weak cross came in just after the break and, under no pressure, Barry decided to divert the ball towards Hart only to send it into the corner of the net with the keeper beaten.
"I think that's our best performance...and we got exactly what we deserved," Southampton captain Lambert told ESPN TV.
"We needed that (own goal) in the second half to open up the gap and give us some breathing space."
Spurs' Wales midfielder Bale netted his fourth and fifth goals in four games for club and country to again inspire the north Londoners in the fourth and final Champions League spot.
Bale struck first with a dipping free kick after five minutes with James Perch failing to jump in the visitors' wall before Lewis Holtby wasted three chances to increase the lead.
Newcastle's French forward Yoan Gouffran then grabbed his first Premier League goal since signing last month when his effort was deflected in midway through the first half, but he later needed oxygen for a shin injury and was substituted.
The home side's pressure eventually paid off against a side that had won their last two games when Bale ran through and finished with aplomb after 78 minutes before missing an easy chance for a hat-trick in stoppage time.
Arsenal duo Jack Wilshere and Theo Walcott, instrumental in England's 2-1 friendly win over Brazil, combined to set up Cazorla for the 35th-minute winner.
The Londoners were utterly dominant over Sunderland in the first half but the situation changed after the break with midfielder Wilshere limping off and defender Carl Jenkinson being sent off for two bookings after 62 minutes.
Arsene Wenger's side held on in the face of pressure but Rafael Benitez's Chelsea avoided any late nerves against Wigan.
Ramires finished off in style after a good pass by Fernando Torres for the 23rd-minute opener, and Eden Hazard, back after his three-game ban for kicking a ballboy, doubled the lead.
Shaun Maloney pulled one back after 58 minutes but England's midweek goal hero Frank Lampard again underlined why most Chelsea supporters want him to be offered another contract when he made it 3-1. Marko Marin added a fourth in injury time.
QPR, four points adrift at the bottom, were never in the game at Swansea with striker Loic Remy missing through injury, and fans will be aghast at their weak display.
Cut-price Spanish striker Michu continued his sensational debut Premier League season with two more goals in the 4-1 thumping to take his campaign's tally to 15.
Second-bottom Aston Villa host West Ham United on Sunday (1330 GMT) with Liverpool facing West Bromwich Albion on Monday.